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Mycophenolic Acid and Metabolite

Mycophenolic Acid and Metabolite

Test ID: 


CPT code:




Clinical Use:

Monitor therapeutic levels; evaluate toxicity

Test Information:

Mycophenolic acid (MPA) is the active metabolite of the prodrug, mycophenolate mofetil (MMF). Absorption of the prodrug is rapid following oral administration to the extent that detectable levels are not seen. Similar effects are observed after cessation of IV administration. Once formed, MPA undergoes metabolism to form the pharmacologically inactive phenolic glucuronide metabolite, MPAG. In vivo, MPAG is converted to MPA via enterohepatic recirculation, which results in a secondary peak in the plasma concentration time profile.1 MPA and MPAG are 92% and 87% protein bound, respectively, at usual clinical concentrations.

Specimen Type:

Serum or plasma

Requested Volume: 


Minimum Volume: 

0.3 mL

Container Type: 

Red-top tube or lavender-top (EDTA) tube


Transfer separated serum or plasma to a plastic transport tube.

Storage Instructions:

Room temperature

Stability Requirements:

Temperature Period
Room temperature 14 days
Refrigerated 14 days
Frozen 14 days
Freeze/thaw cycles Stable x3

Rejection Criteria

Gel-barrier tube

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