Mycophenolic Acid and Metabolite
Monitor therapeutic levels; evaluate toxicity
Mycophenolic acid (MPA) is the active metabolite of the prodrug, mycophenolate mofetil (MMF). Absorption of the prodrug is rapid following oral administration to the extent that detectable levels are not seen. Similar effects are observed after cessation of IV administration. Once formed, MPA undergoes metabolism to form the pharmacologically inactive phenolic glucuronide metabolite, MPAG. In vivo, MPAG is converted to MPA via enterohepatic recirculation, which results in a secondary peak in the plasma concentration time profile.1 MPA and MPAG are 92% and 87% protein bound, respectively, at usual clinical concentrations.
Serum or plasma
Red-top tube or lavender-top (EDTA) tube
Transfer separated serum or plasma to a plastic transport tube.
|Room temperature||14 days|
|Freeze/thaw cycles||Stable x3|
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