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Test ID: 


CPT code:




Clinical Use:

Monitor drug levels for optimal therapy

Test Information:

Zonisamide is an antiepileptic drug belonging to the sulfonamide class and is chemically unrelated to other antiepileptic drugs. While the exact mechanism of action is unknown, anticonvulsant activity may be mediated by action at sodium and calcium channels. This action may result in stabilizing neuronal membranes and suppressing neuronal hypersynchronizations. Preliminary studies on smaller population groups has indicated possible other uses for zonisamide in intractable neuropathic pain syndromes and refractory migraine headaches.

Specimen Type:

Serum or plasma

Requested Volume: 

1.2 mL

Minimum Volume: 

0.4 mL (Note: This volume does not allow for repeat testing.)

Container Type: 

Red-top tube or lavender-top (EDTA) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.


Separated serum from cells within 45 minutes of collection and transfer to a plastic transport tube. Separate plasma immediately and transfer to a plastic transport tube for shipment to the laboratory. Trough: Immediately prior to next dose. Steady-state levels are reached within 5 to 15 days in patients on zonisamide monotherapy. .

Storage Instructions:

Room temperature. Refrigerate at 2°C to 8°C if specimen is not tested immediately.

Stability Requirements:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Rejection Criteria

Gel-barrier tube; hemolysis; nonseparated serum or plasma specimen

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