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Zinc Protoporphyrin (ZPP), Screen

Test ID: 


CPT code:




Test Information:

“Free” protoporphyrin is noncomplexed, nonheme protoporphyrin. Lead poisoning is also characterized by elevated plasma and urine δ-aminolevulinic acid and increased urinary coproporphyrin. Urinary porphobilinogen and uroporphyrin are normal to slightly increased. Free erythrocyte protoporphyrin is a sensitive test for lead toxicity or chronic exposure in adults. Erythrocyte protoporphyrin levels should not be used as a screening test for lead poisoning in children. The diagnosis of lead exposure or poisoning includes consideration of environmental exposure, as well as symptoms and abnormal erythrocyte protoporphyrin. This test is not to be used for workplace exposure to lead. If lead testing is required for workplace exposure to lead, please order test 010180.

Increased lead absorption is reported in the presence of iron deficiency.

Specimen Type:

Whole blood

Requested Volume: 

7 mL

Minimum Volume: 

0.2 mL

Container Type: 

Royal blue-top (EDTA) tube or tan-top lead-free tube; submit original tube.


Mix tube thoroughly to avoid clotting.

Storage Instructions:

Room temperature. Stable for five days at room temperature or for seven days when refrigerated.

Rejection Criteria

Clotted specimen; frozen specimen; hemolyzed specimen; icteric specimen

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