VDRL, Cerebrospinal Fluid
CSF Venereal Disease Research Laboratory (VDRL) Test
Test for syphilis, neurosyphilis
A positive VDRL in a spinal fluid uncontaminated by serum is essentially diagnostic of neurosyphilis; however, a negative test may occur in 30% of patients with tabes dorsalis. The CSF VDRL may take years to become nonreactive after adequate therapy. In AIDS patients, serial CSF VDRL determinations may be needed when neurosyphilis is suspected. By requiring either a positive plasma RPR or FTA-ABS, seropositivity of CSF VDRL could increase to 90%.
Cerebrospinal fluid (CSF)
Hemolysis; gross bacterial contamination