Toluene Metabolite Profile

Test ID:

703991

CPT code:

82570, 84600

Clinical Use:

Monitor toluene exposure

Test Information:

o-Cresol poisoning via acute or chronic exposure is manifested by headache, dizziness, vomiting, rapid respiration, dyspnea, weakness, and damage to the lung, liver, and kidneys. o-Cresol, one of the three isomers of cresol (m- and p-cresol are the other two isomers), is introduced into the body from cresol exposure. Cresols are employed as disinfectants and as chemical intermediates in the production of plasticizers and resins. o-Cresol is also a metabolite of toluene, accounting for a small percentage of the absorbed toluene dose.

Specimen Type:

Urine (random)

Requested Volume:

15 mL

Minimum Volume:

6.2 mL

Container Type:

Plastic urine container, no preservative

Collection:

Sampling time is end of shift for industrial exposure monitoring. Metabolites with timing “end of shift” (meaning the last two hours of exposure) are eliminated rapidly with a half-life less than five hours. Such metabolites do not accumulate in the body and, therefore, their timing is critical only in relation to the exposure period.