Tobramycin, Serum, Peak
Test ID:
703987
CPT code:
80200
Synonyms:
AK-Tob™
Nebcin®
TOBI®
Tobrex®
Clinical Use:
Tobramycin is administered to treat serious infections caused by aerobic gram-negative bacilli (eg, a number of the Enterobacteriaceae, P aeruginosa). These include lower respiratory tract, intra-abdominal, soft tissue, bone or joint, wound, and complicated urinary tract infections; bacteremias; and meningitis. Tobramycin frequently is the aminoglycoside of choice for infections caused by P aeruginosa because of its greater in vitro activity against this organism; however, superior clinical efficacy is unproven. It usually is given in combination with an antipseudomonal penicillin for severe, systemic P aeruginosa infections. Some infectious disease experts have preferred the more costly tobramycin to gentamicin for general use in hospitals where resistance is not a problem because it appears to be less nephrotoxic; however, this does not appear to be warranted when all of the available data are evaluated. Amikacin is the aminoglycoside of choice in hospitals where gentamicin and tobramycin resistance is a problem.
Test Information:
Tobramycin is cleared by the kidney, and accumulates in renal tubular cells. Nephrotoxicity is most closely related to the length of time that trough levels are >2 μg/mL. Creatinine levels should be monitored every two to three days as this serves as a useful indicator of impending renal toxicity. The initial toxic result is nonoliguric renal failure that is usually reversible if the drug is discontinued. Continued administration of tobramycin may produce oliguric renal failure. Nephrotoxicity may occur in as many as 10% to 25% of patients receiving aminoglycosides; most of this toxicity can be eliminated by monitoring levels and adjusting dosing schedules accordingly. Aminoglycosides may also cause irreversible ototoxicity that manifests itself clinically as hearing loss. Aminoglycoside ototoxicity is relatively uncommon and clinical trials where levels were carefully monitored and dosing adjusted failed to show a correlation between auditory toxicity and plasma aminoglycoside levels. In situations where dosing is not adjusted, however, sustained high levels may be associated with ototoxicity. This association is far from clear cut, and new once-daily dosing regimens (and associated high peak serum concentrations) that fail to enhance toxicity further complicate this issue.
Specimen Type:
Serum or plasma
Requested Volume:
1 mL
Minimum Volume:
0.3 mL
Container Type:
Red-top tube or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant
Collection:
Transfer separated serum or plasma to a plastic transport tube. Both peak and trough concentrations should be monitored. The trough sample is drawn immediately prior to the next dose. Peak samples should be drawn 60 minutes after an I.M. injection, 30 minutes after the end of a 30-minute I.V. infusion or immediately after a 60-minute I.V. infusion.
Storage Instructions:
Room temperature
Stability Requirements:
Temperature |
Period |
---|---|
Room temperature |
14 days |
Refrigerated |
14 days |
Frozen |
14 days |
Freeze/thaw cycles |
Stable x3 |
Rejection Criteria
Gel-barrier tube; severe hemolysis; lipemia; icteric specimen
Return Back to Test Directory
MCI Diagnostic
Providing top patient care with fast results.
Hours of Operation
Mon - Sat: 7 AM-11 PM
Sun: 7 AM-3 PM
COVID-19 Drive-Thru Hours
Mon-Fri: 9 AM-6 PM
Federal Holidays - CLOSED
More Information - Click Here
Government Contract
DUNS # 125722608
Cage Code: 3FPQ3
COVID-19
COVID-19 Fee & Pricing