Thyrotropin Receptor Antibody, Serum
Long-acting Thyroid Stimulator
Thyrotropin-binding Inhibitory Immunoglobulin
TSH Receptor Antibody
TSH Receptor-binding Inhibitory Immunoglobulin
Diagnosis of hyperthyroidism and Graves’ disease
Thyrotropin-receptor antibody is an autoantibody to the thyroid cell receptor for thyroid-stimulating hormone. It can be demonstrated in 90% of patients with Graves’ disease, and is the cause of the hyperthyroidism of that condition. The characterization of TRA resolved much confusion about long-acting thyroid stimulator (LATS) and LATS protector, which are both, in fact, thyroid-stimulating autoantibodies which simply behaved differently in animal test systems. These antibodies are present in 50% of euthyroid Graves’ disease as well as hyperthyroid patients. They play a major role in the pathogenesis of Graves’ disease. Detection of these antibodies is useful in prediction of neonatal hyperthyroidism and prediction of relapse of hyperthyroidism.
Red-top tube or gel-barrier tube
It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
If tube other than a gel-barrier tube is used, transfer separated serum to a plastic transport tube.
stable for three days. Stable frozen for one month.
Citrate plasma specimen; samples collected in heparin or samples from patients on heparin therapy; lipemic or hemolyzed serum samples; improper labeling