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Thiopurine Methyltransferase (TPMT), Enzyme Activity, Erythrocytes

Test ID: 

706374

CPT code:

82657

Synonyms:

Thiopurine Methyltransferase (TPMT), Enzyme Activity, Erythrocytes
TPMT Biochemical Assay, Myelotoxicity

Clinical Use:

Determination of TPMT levels that may be associated with toxicity of anticancer and anti-inflammatory drugs

Test Information:

Limitations
For patients having an intrinsic low level of TPMT, recent RBC transfusion can variably increase their assayed enzymatic activity depending on the amount and circulating half-life of the transfused red blood cells.

Specimen Type:

Whole blood

Requested Volume: 

8 mL adults; 5 mL pediatric

Minimum Volume: 

5 mL

Container Type: 

Green-top (sodium heparin) tube or lavender-top (EDTA) tube

Storage Instructions:

Refrigerate.

Stability Requirements:

Temperature

Period

Refrigerated

14 days

Frozen

Unstable

Freeze/thaw cycles

Unstable

Rejection Criteria

Frozen specimen; gross hemolysis; clotted specimen

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