Sjögren’s Antibodies (Anti-SS-A/Anti-SS-B)

Test ID: 

706360

CPT code:

86235 (x2)

Synonyms:

Anti-La

Anti-Ro

Clinical Use:

Aids in the diagnosis of Sjögren’s syndrome (especially with vasculitis) and lupus patients with Sjögren’s overlap syndrome

Test Information:

SS-A(Ro) is found in 60% to 70% of patients with Sjögren’s syndrome and 30% to 40% of patients with SLE. SS-B(La) is found in 50% to 60% of Sjögren’s syndrome and 10% to 15% of SLE. SS-A cannot be demonstrated by immunofluorescence (it is soluble in the buffers used), but SS-B may be seen as a speckled antinuclear pattern. SS-A and SS-B are particularly useful in “ANA-negative” cases of SLE, being present in a majority of such cases. Patients who are ANA-positive and who have SS-A but not SS-B are very likely to have nephritis. Antibodies to SS-A are also associated with HLA loci DR3 and DR2 and with hereditary deficiency of C2. Anti-SS-A and anti-SS-B are found in virtually all children with neonatal lupus. Patients with SS-A may also have antibodies to cardiolipin, lupus anticoagulant, and clinical thromboses. This has been termed antiphospholipid antibody syndrome.

Specimen Type:

Serum

Requested Volume: 

1 mL

Minimum Volume: 

0.5 mL

Container Type: 

Red-top tube or gel-barrier tube

Storage Instructions:

Room temperature

Stability Requirements:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Rejection Criteria

Hemolysis; icterus; lipemia; bacterial contamination

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