Sirolimus (Rapamune)

Test ID: 

703961

CPT code:

80195

Synonyms:

Sirolimus, Whole Blood

Rapamune®

Clinical Use:

Monitor immunosuppressive therapy following organ transplant

Test Information:

Sirolimus may be administered in conjunction with cyclosporine (CsA) and corticosteroids to reduce or prevent host graft rejection. Using this therapy, peak concentrations are achieved in one to two hours. The mean terminal elimination half-life is 62 hours. Drug-drug interactions, including CsA, may alter the pharmacokinetics of sirolimus, making therapeutic drug monitoring appropriate.

Specimen Type:

Whole blood

Requested Volume: 

3 mL

Minimum Volume: 

1.1 mL

Container Type: 

Lavender-top (EDTA) tube

Collection:

Trough: 30 minutes to one hour before the next oral dose

Storage Instructions:

Room temperature

Stability Requirements:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Rejection Criteria

Clotted specimen

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