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Islet Cell Dysfunction Test Group

Test ID: 


CPT code:

84206, 83525


Islet Cell Dysfunction Group 1

Proinsulin:Insulin Ratio

Clinical Use:

The proinsulin:insulin ratio may be useful in managing type 2 diabetic patients. High basal proinsulin:insulin ratio in noninsulin-dependent diabetic patients may predict acute beta-cell dysfunction.

Specimen Type:

Serum (preferred) or plasma, frozen

Requested Volume: 

1 mL

Minimum Volume: 

0.6 mL

Container Type: 

Red-top tube, gel-barrier tube, lavender-top (EDTA) tube, or green-top (heparin) tube

Patient Preparation: 

Under various protocols, the patient may be fasting and drawn, or fasting and drawn after a glucose load.


Separate serum or plasma from cells within 45 minute of collection. Send serum or plasma in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions:


Stability Requirements:

Stable for 200 days. Stable at room temperature for six hours or refrigerated for 24 hours.

Rejection Criteria

Quantity not sufficient for analysis

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