Interleukin-2 Soluble Receptor Alpha
Interleukin-2 Soluble Receptor α
The function of IL-2 sRα is unclear. Increased levels of IL-2 sRα in biological fluids correlate with increased T & B activation and immune system activation. Results of a number of studies suggest a correlation between levels of IL-2 sRα in serum with the onset of rejection episodes in allograft recipients.
The interleukin-2 (IL-2) receptor complex is an αβγ trimer, in which all three chains are in contact with the ligand. The α subunit of this complex, IL-2Rα (also known at Tac antigen and a CD25) is a 55-kilodalton transmembrane glycoprotein with only 13 amino acids of 351 located on the cytoplasmic side of the membrane. A soluble form of IL-2Rα appears in serum, concomitant with its increased expression on cells. Increased levels of the soluble IL-2Rα in biological fluids correlate with activation of T and/or B cells. Results of a number of studies suggest a correlation of levels of IL-2Rα in serum with disease activity in autoimmune and infectious disorders as well as in transplantation rejection. Markedly increased IL-2sRα levels have been associated with hematologic malignancies. Levels of IL-2Rα correlate with tumor burden and response to therapy in numerous malignancies. IL-2Rα levels can be used to predict the long-term prognosis in non-Hodgkin lymphoma patients and to assess the status of patients with HIV and acquired immunodeficiency.
Red-top tube or gel-barrier tube
Transfer the serum into a transpak frozen purple tube with screw cap. Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen specimens, please submit frozen specimens for each test requested.
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