Insulin-like Growth Factor-binding Protein 1 (IGFBP-1)

Test ID: 


CPT code:



IGF-binding Protein 1


Clinical Use:

Identify women who are at high risk for developing preëclampsia

Test Information:

Insulin-like growth factor-binding protein 1 is a member of the family of structurally homologous proteins that specifically binds and modulates the activities of IGF-1 and IGF-2. IGFBP-1 is a 25 kilodalton protein that is produced predominantly by hepatocytes and decidualized ovarian endometrium.3 Serum levels of IGFBP-1 exhibit considerable diurnal variation with levels highest early in the morning and lowest in the evening. Serum IGFBP-1 levels are controlled by insulin with the postprandial increase in insulin levels producing a four- to fivefold decrease in IGFBP-1 levels relative to fasting levels. IGFBP-1 levels have been shown to be elevated in type 1 diabetics and in patients with insulin resistance syndromes. Type 2 diabetics tend to have low serum IGFBP-1 levels. Patients with growth hormone deficiency tend to have elevated IGFBP-1 levels. Low levels are observed in acromegaly, Cushing disease, and polycystic ovary syndrome. IGFBP-1 is the predominant IGF-binding protein in amniotic fluid and in fetal and maternal circulation. The levels are high in the fetus and newborn, but decline steadily until puberty. In a recent study of women in the second trimester of pregnancy, IGFBP-1 levels were higher in women who subsequently developed preëclampsia than in matched controls who did not develop the syndrome.

Specimen Type:

Serum, frozen

Requested Volume: 

0.5 mL

Minimum Volume: 

0.1 mL

Container Type: 

Red-top tube or gel-barrier tube


Transfer the serum into a PP transpak frozen purple tube with screw cap. Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions:


Stability Requirements:



Room temperature

1 day


2 days


16 months

Freeze/thaw cycles

Stable x6

Rejection Criteria

Plasma specimens

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