Immunoglobulin A

Test ID: 

705141

CPT code:

82784

Synonyms:

Immunoglobulin A, Quantitative

IgA, Serum

Quantitative IgA, Serum

Clinical Use:

Evaluate humoral immunity; monitor therapy in IgA myeloma

Test Information:

Increased monoclonal IgA may be produced in lymphoproliferative disorders, especially multiple myeloma and “Mediterranean” lymphoma involving bowel. An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces, where IgA is largely produced. Some clinically significant IgA deficiencies have concomitant deficiencies of IgG2 and IgG4. IgA may be decreased in patients with chronic sinopulmonary disease, in ataxia-telangiectasia, or congenitally. Patients with congenital IgA deficiency are prone to autoimmune diseases, and may develop antibody to IgA and anaphylaxis if transfused. IgA levels may rise with exercise and fall during pregnancy.

Specimen Type:

Serum

Requested Volume: 

1 mL (adult), 0.4 mL (pediatric)

Container Type: 

Red-top tube or gel-barrier tube

Storage Instructions:

Samples suspected of having macroglobulins or cryoglobulins should be drawn and held at 37°C. Samples suspected of containing cold agglutinins should not be refrigerated prior to serum separation from clot.

Stability Requirements:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Rejection Criteria

Excessive lipemia

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