Human T-Cell Lymphotropic Virus I, II (HTLV-I/HTLV-II) Qual

Test ID:

706243

CPT code:

86790

Synonyms:

Human T-Cell Lymphotropic Virus 1, 2 (HTLV-1/HTLV-2) Antibodies, Preliminary Test With Confirmation
HTLV-I/HTLV-II

Clinical Use:

Screen patients for infection with human T-lymphotropic virus and, if positive, confirm infection with either HTLV-1 or HTLV-2

Test Information:

HTLV-1 or HTLV-2 immunoblot testing should only be performed on patient specimens previously found positive for HTLV infection by immunoassay (EIA).

HTLV-1, a human type C retrovirus, is associated with adult T-cell leukemia, tropical spastic paraparesis, and other demyelinating and neoplastic conditions. More recently, HTLV-1 infection has been shown to be associated with T- and B-cell chronic lymphocytic leukemias (CLL), multiple myeloma, some cases of non-Hodgkin lymphoma, polymyositis, arthritis, Kaposi sarcoma, uveitis, strongyloidiasis, and mycosis fungoides. Type 1 HTLV is irregularly distributed throughout the world, as opposed to type 2 virus, which is a new world virus, more common among Americans in North, Central, and South America. HTLV-2 was first isolated from a patient with T-lymphocytic hairy cell leukemia but has not been unequivocally proven to be a pathogen. Recent findings suggest that HTLV-2 may be associated with a number of other leukemias and lymphomas. A high rate of HTLV-2 seropositives has been observed among intravenous drug users. Both HTLV-1 and HTLV-2 are tropic for CD4 lymphocytes and can be transmitted by sexual contact, IV drug use, blood products, transplacentally, and through breast milk.