Human Antimouse Antibodies

Test ID: 

702991

CPT code:

83520

Synonyms:

HAMA

Clinical Use:

This test is intended for the detection and semi-quantitation of human antibodies to mouse IgG (HAMA).

Test Information:

The presence of Rheumatoid Factor (RF) and/or heterophilic antibodies in the sample may interfere with the assay and could result in false-positive values. Lipemic serum samples may interfere with the assay and could result in false-positive values.
The presence of human anti-mouse antibody (HAMA) has been associated with injections of murine monoclonal antibody for diagnostic and/or therapeutic purposes.1-13 Circulating levels of HAMA can bind to the injected IgG and reduce the efficacy of the antibody therapy. HAMA also can cause anaphylactic complications to subsequent administration of murine monoclonal IgG. Several studies have shown a correlation between HAMA status and clinical outcomes and prognosis.6-13 HAMA reactivity has been reported to occur in some individuals without known exposure to murine IgG. Such responses may be due to polyclonal rheumatoid factors, heterophilic antibodies, dietary, or other exposure. HAMA has been shown to interfere with some two-site immunometric assays utilizing murine monoclonal antibodies, resulting in both false positive or false-negative results.14,

Specimen Type:

Serum

Requested Volume: 

0.4 mL

Minimum Volume: 

0.2 mL

Container Type: 

Red-top tube or gel-barrier tube

Collection:

If a red-top tube is used, transfer separated serum to a plastic transport tube.

Storage Instructions:

Refrigerate

Rejection Criteria

Nonserum specimen; gross lipemia

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