HLA B5701 Test
HLA B*57:01, Abacavir Hypersensitivity HLA Association Test
Abacavir Hypersensitivity HLA Association
HLA Antigen B*57:01
Determine the presence of B57 antigen
Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, an additional specimen should be collected for testing.
Abacavir hypersensitivity has been shown to be associated with the human leukocyte antigen (HLA) B*57:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T cell receptors to elicit an immune response. The presence of the HLA-B*57:01 allele increases the susceptibility to abacavir hypersensitivity in several populations studied.
Whole blood or buccal swabs
7 mL whole blood or four buccal swabs
3 mL whole blood or four buccal swabs
Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). When submitting buccal swabs, please use a buccal swab kit.
Maintain blood specimen at room temperature. Keep buccal swabs dry and at room temperature.
Hemolysis; clotted specimen; insufficient amount of DNA on buccal swabs
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