HLA B5701 Test

Test ID: 

706625

CPT code:

81381

Synonyms:

HLA B*57:01, Abacavir Hypersensitivity HLA Association Test
Abacavir Hypersensitivity HLA Association
B*5701
B*57:01
B5701
HLA Antigen B*57:01

Clinical Use:

Determine the presence of B57 antigen

Test Information:

Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, an additional specimen should be collected for testing.
Abacavir hypersensitivity has been shown to be associated with the human leukocyte antigen (HLA) B*57:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T cell receptors to elicit an immune response. The presence of the HLA-B*57:01 allele increases the susceptibility to abacavir hypersensitivity in several populations studied.

Specimen Type:

Whole blood or buccal swabs

Requested Volume: 

7 mL whole blood or four buccal swabs

Minimum Volume: 

3 mL whole blood or four buccal swabs

Container Type: 

Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). When submitting buccal swabs, please use a buccal swab kit.

Storage Instructions:

Maintain blood specimen at room temperature. Keep buccal swabs dry and at room temperature.

Rejection Criteria

Hemolysis; clotted specimen; insufficient amount of DNA on buccal swabs