Growth Hormone Binding Protein (GHBP)

Test ID: 

704161

CPT code:

83519

Clinical Use:

Reduced or absent GHBP is found in GH insensitivity due to inactivating receptor binding mutations as typified by Laron dwarfism. The most clinically relevant use of GHBP measurements is to confirm suspected Laron dwarf GH insensitivity due to genetic GH receptor defect. Other forms of GH receptor insensitivity, however may have normal or high GHBP levels. The levels of GHBP may be explained by the underlying mechanism for insensitivity, accordingly, inability to dimerize, errors in the trans-membrane structure, or in downstream actions may have high or normal GHBP levels.

Specimen Type:

Serum

Requested Volume: 

0.3 mL

Minimum Volume: 

0.1 mL

Container Type: 

Gel-barrier tube; red-top tube

Collection:

Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection. Send serum in a plastic transport tube.

Storage Instructions:

Refrigerate

Stability Requirements:

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x6

 

 

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