Foscarnet Resistance HSV (Phenotype)
Herpes Simplex Types 1 and 2 Virus Phenotyping for Foscarnet Drug
This test method uses a plaque reduction assay. It measures the extent to which various concentrations of foscarnet inhibit the growth of virus in cell culture. The concentration of drug which results in a 50% reduction in plaque formation induced by viral cytopathic effect (CPE) versus the no-drug control establishes an inhibitory dose (ID-50) drug concentration reportable value.
Actively-growing isolate (preferred) or eye, genital, oral, urethral, vesicle, or throat swab
One tube with media or one swab
Isolate in tube with media capped tightly or swab in viral transport media
Maintain isolate at room temperature. Refrigerate viral transport media with swab.