DPD 5-Fluorouracil Toxicity
Test ID:
706604
CPT code:
81232
Synonyms:
5FU
Dihydropyrimidine Dehydrogenase
Clinical Use:
Variability in response (efficacy and toxicity) to 5-fluorouracil (5-FU) chemotherapy has been linked to the rate-limiting enzyme in the drug’s catabolic pathway, known as dihydropyrimidine dehydrogenase (DPD).
Test Information:
DPD deficiency results in excessive amounts of 5-FU available to be anabolized to its active metabolite and is relatively undetectable by clinical observation prior to 5-FU administration. Extensive studies have associated both profound and partial deficiency in DPD activity with severe unanticipated toxicity after 5-FU administration. Numerous studies genotyping DPD deficient patients, their family members, and healthy individuals have shown that the splice-site mutation (IVS14+1G>A) is the most characterized and frequently observed allele associated with decreased DPD enzyme activity. Screening for the presence of this mutation in the Caucasian population showed frequencies of 0.91% homozygous and 1.8% heterozygous for the IVS14+1G>A allele.
Specimen Type:
Whole blood or buccal swab kit (buccal swab collection kit contains instructions for use of a buccal swab)
Requested Volume:
7mL
Minimum Volume:
3mL
Container Type:
Lavender-top (EDTA) tube, yellow-top (ACD) tube, or buccal swab kit
Storage Instructions:
Maintain specimen at room temperature or refrigerate at 4°C.
Rejection Criteria:
Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; one buccal swab; wet buccal swab
Return Back to Test Directory
MCI Diagnostic
Providing top patient care with fast results.
7018 South Utica Avenue
Tulsa, Oklahoma 74136
Hours of Operation
Mon - Sat: 7 AM-11 PM
Sun: 7 AM-3 PM
COVID-19 Drive-Thru Hours
Mon-Fri: 9 AM-6 PM
Sat: 9 AM-3 PM
More Information - Click Here
Government Contract
DUNS # 125722608
Cage Code: 3FPQ3
COVID-19
COVID-19 Fee & Pricing