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Dibucaine Number Cholinesterase

Test ID: 


CPT code:



Dibucaine Inhibition

Clinical Use:

Assess the presence of homozygous or heterozygous “atypical” cholinesterase variant, in patients who have low result of serum or plasma cholinesterase assay, and may be at risk of apnea when given succinylcholine muscle relaxant

Test Information:

This approach to detection of serum or plasma cholinesterase variants does not entirely avoid the problem of variation in reactivity with some atypical enzymes.

Specimen Type:

Serum or plasma

Requested Volume: 

2 mL serum and 5 mL whole blood


Minimum Volume: 

0.1 mL serum and 1 mL whole blood

Container Type: 

Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube

Patient Preparation: 

Do not collect within 24 hours of administration of muscle relaxant.


Separate serum or plasma from cells and place in transport tube. Mark transport tube appropriately “serum” or “plasma.”

Storage Instructions:

Room temperature

Rejection Criteria

Plasma or serum not separated from cells; frozen whole blood received; hemolysis

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