Diabetes Autoimmune Profile

Test ID: 

704349

CPT code:

86337, 83519, 86341 (x2)

Clinical Use:

Diabetes autoantibodies assessment is helpful in identifying and managing patients at risk for development of type 1 diabetes. Published positivity rates for diabetes autoantibodies in new-onset type 1 diabetes patients listed below are based on the combined analysis of GAD-65, ICA 512, insulin antibodies, and ZnT8 antibodies.

Positive rate in new-onset type 1 diabetes patients:

• GAD-65 antibodies = 68% positive

• ICA 512 antibodies = 72% positive

• Insulin antibodies = 55% positive

• ZnT8 antibodies = 63% positive

An increase in the number of positive antibodies is associated with a higher likelihood of type 1 diabetes.

Specimen Type:

Serum, frozen

Requested Volume: 

2.5 mL

Minimum Volume: 

1.0 mL (Note: This volume does not allow for repeat testing.)

Container Type: 

Red-top tube or gel-barrier tube

Collection:

Transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions:

Freeze. Stable at room temperature or refrigerated for one day. Stable frozen for seven days. Freeze/thaw cycles: stable x3.

Rejection Criteria

Gross hemolysis; lipemic specimen; EDTA plasma

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