Complement C2

Test ID: 

704795

CPT code:

86160

Synonyms:

C2 Complement

Clinical Use:

Assess patients with hereditary deficiency of this component or acquired decrease in its level which may be seen due to hypercatabolism in hereditary angioneurotic edema, or consumption or loss as in vasculitides, glomerulonephritides, immune complex diseases. C2 deficiency is the most common complement deficiency (1 in 10,000) and is associated with SLE.

Test Information:

Deficiencies of C1 components, C2 and C4 are associated with rheumatic diseases, including lupus, vasculitis, and dermatomyositis. Some individuals with deficiency may have no evidence of disease. The most common complement deficiency is C2, which is a homozygous abnormality in 1 in 10,000 to 40,000 individuals, and is heterozygous in 1% to 2% of the general population. Patients with C2 deficiency and lupus often have negative or low titer ANA.

Specimen Type:

Serum

Requested Volume: 

2 mL

Minimum Volume: 

0.1 mL

Container Type: 

Red-top tube or gel-barrier tube

Collection:

Separate serum from cells.

Storage Instructions:

Room temperature

Stability Requirements:

Temperature

Period

Room temperature

12 days

Refrigerated

12 days

Frozen

12 days

Freeze/thaw cycles

Stable x3

Rejection Criteria

Excessive hemolysis; plasma specimen

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