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Complement C2

Test ID: 


CPT code:



C2 Complement

Clinical Use:

Assess patients with hereditary deficiency of this component or acquired decrease in its level which may be seen due to hypercatabolism in hereditary angioneurotic edema, or consumption or loss as in vasculitides, glomerulonephritides, immune complex diseases. C2 deficiency is the most common complement deficiency (1 in 10,000) and is associated with SLE.

Test Information:

Deficiencies of C1 components, C2 and C4 are associated with rheumatic diseases, including lupus, vasculitis, and dermatomyositis. Some individuals with deficiency may have no evidence of disease. The most common complement deficiency is C2, which is a homozygous abnormality in 1 in 10,000 to 40,000 individuals, and is heterozygous in 1% to 2% of the general population. Patients with C2 deficiency and lupus often have negative or low titer ANA.

Specimen Type:


Requested Volume: 

2 mL

Minimum Volume: 

0.1 mL

Container Type: 

Red-top tube or gel-barrier tube


Separate serum from cells.

Storage Instructions:

Room temperature

Stability Requirements:



Room temperature

12 days


12 days


12 days

Freeze/thaw cycles

Stable x3

Rejection Criteria

Excessive hemolysis; plasma specimen

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