Clomipramine (Anafranil®)

Test ID: 


CPT code:





Clinical Use:

Evaluate toxicity; monitor therapeutic levels

Test Information:

The drug is used in the treatment of obsessive-compulsive disorder (OCD) and in the treatment of depression and panic attacks. Clomipramine is well absorbed orally but probably undergoes significant first-pass metabolism. Metabolism may be dose-related (capacity limited), which should be kept in mind when using large doses (eg, >150 mg/day). Due to enzyme inhibition, coadministration of valproic acid may produce elevated levels of clomipramine with resultant seizures. Time to peak plasma concentration is two to six hours. Protein binding is about 95%, and the apparent volume of distribution is 12 L/kg. The major hepatic metabolite is norclomipramine, which has biologic activity. The terminal elimination mean half-life ranges from 31 to 37 hours. Total body clearance is 12.5 mL/kg/minute. Metabolites are eliminated in urine and feces.

Specimen Type:

Serum or plasma

Requested Volume: 

1 mL

Minimum Volume: 

0.2 mL

Container Type: 

Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.


Transfer separated serum or plasma to a plastic transport tube. For therapeutic monitoring, collect specimen immediately prior to next dose.

Storage Instructions:

Maintain specimen at room temperature.

Stability Requirements:



Room temperature

67 hours


14 days


14 days

Rejection Criteria

Gel-barrier tube

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MCI Diagnostic

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Sun: 7AM-3PM

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