Ceruloplasmin
Test ID:
702828
CPT code:
82390
Clinical Use:
Decreased in most instances of Wilson’s disease (hepatolenticular degeneration); hence, ceruloplasmin is used in evaluation of chronic active hepatitis, cirrhosis, and other liver disease. In Wilson’s disease, there is decreased ability to incorporate copper into apoceruloplasmin. As a result, free copper levels in plasma and in tissue, especially liver and brain, are greatly increased.
Test Information:
Ceruloplasmin is an α2-globulin containing copper. About 70% or more of total serum copper is associated with ceruloplasmin, 7% with a high MW protein, transcuprein, 19% with albumin, and 2% with amino acids.
Specimen Type:
Serum (preferred) or plasma
Requested Volume:
Serum (preferred) or plasma
Container Type:
Red-top tube, gel-barrier tube, or green-top (heparin) tube
Collection:
Draw blood in gel-barrier tube (preferred). Separate serum or plasma from cells within 45 minutes of collection. Transfer separated serum or plasma to a plastic transport tube.
Storage Instructions:
Refrigerate.
Stability Requirements:
Temperature Period
Room temperature 7 days
Refrigerated 14 days
Frozen 14 days
Freeze/thaw cycles Stable x3
Rejection Criteria
Hemolyzed specimen; specimen with improper identification
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