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Test ID: 


CPT code:


Clinical Use:

Decreased in most instances of Wilson’s disease (hepatolenticular degeneration); hence, ceruloplasmin is used in evaluation of chronic active hepatitis, cirrhosis, and other liver disease. In Wilson’s disease, there is decreased ability to incorporate copper into apoceruloplasmin. As a result, free copper levels in plasma and in tissue, especially liver and brain, are greatly increased.

Test Information:

Ceruloplasmin is an α2-globulin containing copper. About 70% or more of total serum copper is associated with ceruloplasmin, 7% with a high MW protein, transcuprein, 19% with albumin, and 2% with amino acids.

Specimen Type:

Serum (preferred) or plasma

Requested Volume: 

Serum (preferred) or plasma

Container Type: 

Red-top tube, gel-barrier tube, or green-top (heparin) tube


Draw blood in gel-barrier tube (preferred). Separate serum or plasma from cells within 45 minutes of collection. Transfer separated serum or plasma to a plastic transport tube.

Storage Instructions:


Stability Requirements:

Temperature                    Period
Room temperature          7 days
Refrigerated                    14 days
Frozen                            14 days
Freeze/thaw cycles        Stable x3

Rejection Criteria

Hemolyzed specimen; specimen with improper identification

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