BCR-ABL1, CML/ALL, PCR, Quant
Test ID:
706587
CPT code:
81206; 81207
Synonyms:
Acute Lymphocytic Leukemia
BCR-ABL1 Transcript Detection by RT-PCR
Quantitative-Chronic Myelogenous Leukemia
BCR-ABL1 Transcript Detection by RT-PCR
Quantitative – Quantitative BCR-ABL1 Translocation Detection by RT-PCR for CML and ALL
Clinical Use:
This assay can detect three different types of BCR-ABL1 fusion transcripts associated with CML, ALL, and AML:e13a2 (previously b2a2) and e14a2 (previously b3a2) (major breakpoint, p210), as well as e1a2 (minor breakpoint, p190). The e13a2 and e14a2 transcript values are titrated to the current International Scale (IS). The standardized baseline is 100% BCR-ABL1 (IS) and major molecular response (MMR) is equivalent to 0.1% BCR-ABL1 (IS) corresponding to a 3-log reduction. Results should be correlated with appropriate clinical and laboratory information as indicated.
Specimen Type:
Whole blood, bone marrow, or cell pellet
Requested Volume:
5 mL whole blood OR
2 mL bone marrow
Minimum Volume:
3 mL whole blood OR
1 mL bone marrow
Container Type:
Lavender-top (EDTA) tube, green-top (sodium heparin) tube, or yellow-top (ACD-A) tube
Collection:
Submit at room temperature. Specimens should arrive in the laboratory within 48 hours of collection. Indicate date and time of collection on test request form.
Storage Instructions:
Submit at room temperature. If specimen has to be stored more than 48 hours, refrigerate at 2°C to 8°C.
Rejection Criteria
Specimen does not meet collection criteria; frozen whole blood or marrow; leaking tube; clotted blood or marrow; grossly hemolyzed; otherwise visibly degraded; contamination by another specimen; containing suspicious foreign material
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MCI Diagnostic
Providing top patient care with fast results.
7018 South Utica Avenue
Tulsa, Oklahoma 74136
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Mon - Sat: 7 AM-11 PM
Sun: 7 AM-3 PM
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