B Cell Panel (IgH, IgK)

Test ID: 

706585

CPT code:

81261; 81264

Synonyms:

B-Cell Gene Rearrangements Profile, IgH and IgK

IgH Clonality Assay

IgH Gene Rearrangement Assay

IgK Clonality Assay

IgK Gene Rearrangement Assay

Clinical Use:

This profile can be used to detect clonal B-cell immunoglobulin heavy chain (IgH) and immunoglobulin κ light chain (IgK) gene rearrangements in blood, bone marrow, and tissue specimens with combined B-cell clonality detection rate of 99%. The presence of a monoclonal gene rearrangement usually, but not always, reflects the presence of a B-lymphocytic neoplasm, while polyclonal gene rearrangement patterns are found in benign reactive condition. Thus, the results of these studies can assist in the diagnosis of lymphoproliferative disorders.

Specimen Type:

Whole blood, bone marrow, formalin-fixed, paraffin-embedded (FFPE) tissue block or slides, fresh or frozen tissue

Requested Volume: 

3 to 5 mL whole blood, 1 mL bone marrow, five unstained slides at 10 μM or formalin-fixed, paraffin-embedded tissue block, tissue in RPMI or frozen

Minimum Volume: 

0.5 mL whole blood, 0.5 mL bone marrow, two unstained slides at 10 μM

Container Type: 

Lavender-top (EDTA) tube, yellow-top (ACD) tube, green-top (heparin) tube, FFPE tissue block or slides, or tissue in RPMI or frozen

Collection:

Fresh tissue should be placed in RPMI medium or shipped frozen on dry ice. Small samples (eg, punch biopsies, fine-needle aspirates) will also be accepted. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate specimens for each test requested.

Storage Instructions:

Maintain blood, bone marrow or tissue in RPMI at 2°C to 8°C; FFPE specimens at room temperature; tissue at -80°C.

Rejection Criteria

Frozen whole blood/bone marrow; quantity not sufficient for analysis; tumor tissue; broken or stained slides

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MCI Diagnostic

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