Aspergillus Ag, BAL/Serum
Aspergillus Galactomannan Antigen Detection, Bronchoalveolar Lavage or Serum
Patients diagnosed with chronic granulomatous disease and/or Job’s syndrome may yield a reduced detection of galactomannan.1 Reduced assay sensitivity may occur in patients receiving concomitant antifungal therapy.2Penicillium species, Alternaria species, Paecilomyces species, Geotrichum species, and Histoplasma species have demonstrated reactivity with the monoclonal antibodies used in the assay and may, therefore, yield a positive test result. Positive results in patients with no clinical signs of disease have been reported, especially in young children
Serum or bronchoalveolar lavage (BAL)
Serum: Red-top tube or gel-barrier tube
BAL: sterile screw-cap, leakproof container
Usual aseptic technique
Collect specimen using aseptic technique. Avoid opening the specimen after collection. Do not aliquot (Package insert (PI) specifies transport in sealed tubes).
Storage: Refrigerate unopened at 2°C to 8°C for five days. After opening, store at 2°C to 8°C for 48 hours. Freeze at: -70°C after five days.
Unlabeled specimen or name discrepancy between specimen and test request form; blood collected in collection tubes other than those specified; grossly hemolyzed, lipemic, or icteric blood specimens; respiratory specimens other than BAL; inadequate specimen volume; specimen received after the specified time or improperly stored/transported; specimen source other than BAL or serum.
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