Antiscleroderma – 70 Antibodies
Test ID:
706002
CPT code:
86235
Synonyms:
Anti-Scl 70
Clinical Use:
Differential diagnosis of scleroderma (progressive systemic sclerosis)
Test Information:
Scl-70 antibody is seen in 20% of patients with scleroderma, and in some patients with CREST syndrome (calcinosis, Raynaud, esophageal dysfunction, sclerodactyly, telangiectasia). These syndromes are also associated with a high frequency of speckled pattern immunofluorescent antinuclear antibody tests. Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease. In addition, the presence of Scl-70 in Raynaud phenomenon may indicate a poor prognosis.
Specimen Type:
Serum
Requested Volume:
1 mL
Minimum Volume:
0.5 ml (Note: This volume does not allow for repeat testing.)
Container Type:
Red-top tube or gel-barrier tube
Storage Instructions:
Room temperature:
Stability Requirements:
Temperature |
Period |
---|---|
Room temperature |
14 days |
Refrigerated |
14 days |
Frozen |
14 days |
Freeze/thaw cycles |
Stable x3 |
Rejection Criteria
Hemolysis; icterus; lipemia; gross bacterial contamination
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MCI Diagnostic
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