Antiscleroderma – 70 Antibodies

Test ID: 

706002

CPT code:

86235

Synonyms:

Anti-Scl 70

Clinical Use:

Differential diagnosis of scleroderma (progressive systemic sclerosis)

Test Information:

Scl-70 antibody is seen in 20% of patients with scleroderma, and in some patients with CREST syndrome (calcinosis, Raynaud, esophageal dysfunction, sclerodactyly, telangiectasia). These syndromes are also associated with a high frequency of speckled pattern immunofluorescent antinuclear antibody tests. Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease. In addition, the presence of Scl-70 in Raynaud phenomenon may indicate a poor prognosis.

Specimen Type:

Serum

Requested Volume: 

1 mL 

Minimum Volume: 

0.5 ml (Note: This volume does not allow for repeat testing.)

Container Type: 

Red-top tube or gel-barrier tube

Storage Instructions:

Room temperature:

Stability Requirements:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Rejection Criteria

Hemolysis; icterus; lipemia; gross bacterial contamination

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