Antiproteinase 3 (PR3) Antibodies

Test ID: 

704722

CPT code:

83520

Synonyms:

cANCA-specific Antibody

Clinical Use:

For diagnosis and monitoring inflammatory activity in primary systemic small vessel vasculitides. Antineutrophil antibodies are best demonstrated in these diseases by using a combination of IFA and EIAs that detect ANCA specific for PR3-ANCA or MPO-ANCA. Presence of anti-MPO antibodies are highly specific for idiopathic and vasculitis associated crescentic glomerulonephritis, classic polyarteritis nodosa, Churg-Strauss syndrome, and polyangiitis overlap syndrome without renal involvement.

Presence of anti-PR3 antibodies are highly specific for Wegener granulomatous (WG) disease, for which the sensitivity is reported to be 98%. Some patients with WG have pANCA with MPO specificity. About 60% of patients with microscopic polyangiitis or pauci-immune segmental necrotizing glomerulonephritis have pANCA with MPO specificity but 30% have cANCA with PR3 specificity. Levels of anti-PR3 or anti-MPO are elevated during active phases of disease and lower during remission and can be monitored for management of disease.

Specimen Type:

Serum

Requested Volume: 

0.6 mL

Minimum Volume: 

0.3 mL

Container Type: 

Red-top tube or gel-barrier tube

Storage Instructions:

Room temperature

Stability Requirements:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x1

Rejection Criteria

Hemolysis; lipemia; gross bacterial contamination

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