Antineutrophil Cytoplasmic Antibodies (ANCA)

Test ID: 

704717

CPT code:

86256 (x3

Clinical Use:

Antineutrophil cytoplasmic autoantibodies (ANCA) are a serological marker associated with vasculitis and glomerulonephritis. Specifically, ANCA have been found (at frequencies ranging from 70% to 90%) in patients with active Wegener granulomatosis, microscopic polyarteritis nodosa, and idiopathic crescentic glomerulonephritis (with manifestations ranging from kidney-limited disease to extrarenal systemic disease, including pulmonary-renal syndromes). Glomerular lesions in patients with ANCA-associated systemic vasculitis or renal-limited disease are virtually identical. Normal controls are negative for ANCA and <10% of patients with other renal diseases are positive. ANCA may be directly involved in the pathogenesis of the vascular injury that causes the clinical manifestations in ANCA-associated disease.

Specimen Type:

Serum

Requested Volume: 

1 mL

Minimum Volume: 

0.5 (Note: This volume does not allow for repeat testing.)

Container Type: 

Red-top tube or gel-barrier tube

Storage Instructions:

Room temperature

Stability Requirements:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Rejection Criteria

Gross hemolysis; lipemia; bacterial contamination

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MCI Diagnostic

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