Antihistone Antibodies

Test ID: 


CPT code:



DIL/Drug-induced Lupus Antibodies/H2a/H2B and H4 Anitbodies/Histone Antibodies

Clinical Use:

Histones are lysine-rich and arginine-rich basic proteins of eukaryotic cells which are predominantly found as complexes with DNA. Antibodies to histones are detected in approximately 30% to 60% of patients with systemic lupus erythematosus (SLE), but their presence in about 95% of patients with drug-induced lupus is more important diagnostically. Drug-induced lupus (primarily caused by procainamide and hydralazine) is clinically similar to SLE, except that the former patients do not have kidney or central nervous system involvement and they do not demonstrate the multiple types of antinuclear antibodies (ANAs) often found in SLE patients. In addition, drug-induced antihistone antibodies react strongly with H2a/H2b fragments (in procainamide-induced SLE) as well as H3 and H4 (in hydralazine-induced SLE). In patients with drug-induced lupus, antihistone antibodies are usually the only ANAs, although antibodies to denaturated DNA have been detected in a small percentage of patients. Antihistone antibodies also occur in approximately 20% of patients with rheumatoid arthritis.

Specimen Type:


Requested Volume: 

1 mL

Minimum Volume: 

0.5 mL (Note: This volume does not allow for repeat testing.)

Container Type: 

Red-top tube or gel-barrier tube

Storage Instructions:

Maintain specimen at room temperature.

Stability Requirements:



Room temperature

14 days


14 days


14 days

Rejection Criteria

Hemolysis; icterus; lipemia; bacterial contamination

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MCI Diagnostic

Providing top patient care with fast results. 

7018 South Utica Avenue

Tulsa, Oklahoma 74136

Hours of Operation

Mon – Sat: 7AM-11PM

Sun: 7AM-3PM

Government Contract

Mon – Sat: 7AM-11PM

Sun: 7AM-3PM


Mon – Sat: 7AM-11PM

Sun: 7AM-3PM

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