Antifungal Suscep,Amphotericin

Test ID:

705703

CPT code:

87186

Synonyms:

Antifungal Susceptibility Testing
Fungal Susceptibility Testing

Clinical Use:

Routine antifungal susceptibility testing is not recommended. Testing may be warranted under certain circumstances such as:

• Aid in patient management of refractory oropharyngeal infections due to Candida spp in patients who appear to be experiencing therapeutic failure of the standard antifungal agents at standard doses

• Aid in management of invasive infections due to Candida spp when the utility of the azole antifungal agents (ie, fluconazole, itraconazole) is uncertain (ie, non-Candida albicans isolate)

• Establish antibiograms for a specific institution

Interpretive categories include the following.

Susceptible: This category implies that an infection due to the strain may be appropriately treated with the dosage of the recommended agent unless otherwise contraindicated.

Intermediate: Susceptibility is not certain since the available data does not permit categorization as either susceptible or resistant.

Susceptible dose dependent: Susceptibility is dependent upon achieving the maximal possible blood level. Doses of 400 mg/day or more of fluconazole may be required in adults with normal renal function. Measures to assure adequate drug absorption and plasma concentration >0.5 μg/mL may be required for optimal response with itraconazole.

Resistant: Strains falling in this category are not inhibited by the usually achievable systemic concentration of the agent with normal dosage schedules and/or fall in the range where specific microbial resistance mechanisms are likely, and/or clinical efficacy has not been reliable in treatment studies.