Antifungal Suscep,Amphotericin
Test ID:
705703
CPT code:
87186
Synonyms:
Antifungal Susceptibility Testing
Fungal Susceptibility Testing
Clinical Use:
Routine antifungal susceptibility testing is not recommended. Testing may be warranted under certain circumstances such as:
• Aid in patient management of refractory oropharyngeal infections due to Candida spp in patients who appear to be experiencing therapeutic failure of the standard antifungal agents at standard doses
• Aid in management of invasive infections due to Candida spp when the utility of the azole antifungal agents (ie, fluconazole, itraconazole) is uncertain (ie, non-Candida albicans isolate)
• Establish antibiograms for a specific institution
Interpretive categories include the following.
Susceptible: This category implies that an infection due to the strain may be appropriately treated with the dosage of the recommended agent unless otherwise contraindicated.
Intermediate: Susceptibility is not certain since the available data does not permit categorization as either susceptible or resistant.
Susceptible dose dependent: Susceptibility is dependent upon achieving the maximal possible blood level. Doses of 400 mg/day or more of fluconazole may be required in adults with normal renal function. Measures to assure adequate drug absorption and plasma concentration >0.5 μg/mL may be required for optimal response with itraconazole.
Resistant: Strains falling in this category are not inhibited by the usually achievable systemic concentration of the agent with normal dosage schedules and/or fall in the range where specific microbial resistance mechanisms are likely, and/or clinical efficacy has not been reliable in treatment studies.
Specimen Type:
Pure culture yeast isolate
Requested Volume:
Pure culture yeast isolate
Container Type:
Mycology or bacterial culture medium (slant or plate) packaged as an etiologic agent (ie, Sabouraud dextrose, SABHI, BHI, chocolate, etc)
Storage Instructions:
Room Temperature
Rejection Criteria
Isolate nonviable; nonyeast isolate (eg, bacteria or mold); unlabeled specimen or name discrepancy between specimen and request label.
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