Antidiuretic Hormone (ADH)

Test ID:

704141

CPT code:

84588

Synonyms:

•Arginine Vasopressin, AVP
•Vasopressin

Clinical Use:

Aid in the diagnosis of urine concentration disorders, especially diabetes insipidus, syndrome of inappropriate ADH (SIADH), psychogenic water intoxication, and syndrome of ectopic ADH production.

Test Information:

ADH, produced in the supraoptic and paraventricular locations of the hypothalamus, acts on the collecting tubules of the kidney to cause increase in permeability to water and urea. ADH release is triggered by a number of both osmotic and nonosmotic stimuli. Measurement of ADH is useful in separating central diabetes insipidus, which is marked by polydipsia and polyuria and is caused by inadequate ADH production from nephrogenic diabetes insipidus caused by the inability of renal tubules to respond to ADH. In SIADH, release of ADH is disproportionate to a low serum osmolality. SIADH results due to a number of conditions such as pulmonary disease, head trauma, and cancer.

Specimen Type:

Plasma, frozen

Requested Volume:

2 mL

Container Type:

Lavender-top (EDTA) tube

Patient Preparation:

No isotopes administered within 24 hours prior to venipuncture.

Collection:

Centrifuge in a refrigerated centrifuge, separate plasma, and freeze immediately. Transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.