Diagnose megaloblastic anemia. Elevated levels of methylmalonic acid provide an early indication of cobalamin (B12) deficiency.
The megaloblastic anemia profile monitors four compounds: methylmalonic acid, 2-methylcitric acid, homocysteine, and cystathionine
Serum or plasma
Red-top tube, gel-barrier tube, or green-top (heparin) tube
Separate serum or plasma from cells within one hour of collection and transfer to a plastic transport tube.
Specimen received not separated from cells; plasma from a blue-top or yellow-top tube; citrate interferes with assay; homocysteine results increase by approximately 35% and 75% for specimens not centrifuged and/or not separated from the clot for periods of four and 24 hours respectively
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