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Amiodarone (Cordarone®), Screen

Test ID: 


CPT code:




Clinical Use:

Amiodarone is a class III antiarrhythmic agent approved for the treatment of life-threatening ventricular tachyarrhythmias. Because of potential toxicity the serum level of this drug should be monitored.1 Its major elimination is by hepatic excretion. Negligible renal excretion occurs. Use of the drug is restricted because of its many side effects, including pulmonary fibrosis, neuromuscular weakness, exacerbation of congestive heart failure, tremor, thyroid dysfunction, and interaction with other drugs. Potassium or magnesium deficiency should be corrected. AST and ALT should be monitored.

Specimen Type:

Serum or plasma

Requested Volume: 

1 mL

Minimum Volume: 

0.3 mL

Container Type: 

Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.


Transfer separated serum or plasma to a plastic transport tube before freezing.

Storage Instructions:


Stability Requirements:



Room temperature

1 day


14 days


14 days

Freeze/thaw cycles

Stable x3

Rejection Criteria

Gel-barrier tube; specimen not frozen

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