Alkaline Phosphatase

Test ID: 


CPT code:


Clinical Use:

Causes of high alkaline phosphatase include bone growth, healing fracture, acromegaly, osteogenic sarcoma, liver or bone metastases, leukemia, myelofibrosis, and rarely myeloma. Alkaline phosphatase is used as a tumor marker

Additional Test Information:

Serum alkaline phosphatase is a member of a family of zinc metalloprotein enzymes that function to split off a terminal phosphate group from an organic phosphate ester. This enzyme functions in an alkaline environment (optimum pH of 10). Active center of ALP enzymes includes a serine residue. Mg and Zn ions are required for minimal activity. Enzyme activity is localized in the brush border of the proximal convoluted tubule of the kidney, intestinal mucosal epithelial cells, hepatic sinusoidal membranes, vascular endothelial cells and osteoblasts of bone. There are distinctive forms of ALP in the placenta and small intestine; hepatic, renal and osteoblast (bone) ALP are similar molecules.

Specimen Type:

Serum (preferred) or plasma

Requested Volume: 

2 mL

Minimum Volume: 

0.5 mL

Container Type: 

Red-top tube, gel-barrier tube, or green-top (heparin) tube


Separate serum or plasma from cells within 45 minutes of collection. If a red-top tube or green-top tube is used, transfer separated serum or plasma to a plastic transport tube.

Storage Instructions:

Room temperature

Rejection Criteria

Hemolysis; plasma specimen; specimen collected in EDTA tube; improper labeling

Return Back to Test Directory

MCI Diagnostic

Providing top patient care with fast results. 

7018 South Utica Avenue

Tulsa, Oklahoma 74136

Hours of Operation

Mon – Sat: 7AM-11PM

Sun: 7AM-3PM

Government Contract

Mon – Sat: 7AM-11PM

Sun: 7AM-3PM


Mon – Sat: 7AM-11PM

Sun: 7AM-3PM

Thank you for uploading your files. Your upload has been submitted successfully.