Histoplasma Gal’mannan Ag Ur

Test ID: 

706623

CPT code:

87385

Synonyms:

Histoplasma Galactomannan Antigen EIA, Urine
Histoplasma Galactomannan Antigen EIA
Histoplasma Urinary Antigen

Clinical Use:

Diagnosis of histoplasmosis based upon detection of antigen

Test Information:

A negative result does not preclude a diagnosis of histoplasmosis. This assay has been documented to cross-react with Blastomyces dermatitidis, Coccidioides immitis, Paracoccidioides brasiliensis, and Penicillium marneffei. Positive tests should be confirmed in areas or patient groups where these organisms are endemic or a risk. The following substances may interfere with the assay results: foods which produce color in urine; vaginal cream; caffeine; ascorbic acid, itraconazole; amphotericin B; acetaminophen; and acetylsalicylic acid.
Antigen detection may be useful in acute disease, especially in individuals also infected with HIV, who frequently have the disseminated form of histoplasmosis without detectable antibodies to the fungus. In chronic disease, antigen may not be detected due to the low fungal burden. The highest sensitivity for rapidly and accurately diagnosing histoplasmosis in patients with acute pulmonary or disseminated infection can be obtained by testing both urine and serum.

Specimen Type:

Urine (unpreserved)

Requested Volume: 

5 mL

Minimum Volume: 

1 mL

Container Type: 

Sterile cup or sterile screw-capped vial

Collection:

Collect specimen aseptically

Storage Instructions:

Refrigerate. Store specimens at 2°C to 8°C or frozen at -16°C to 24°C for up to 14 days.

Expected Turnaround Time:

1 to 2 Days

Rejection Criteria

Specimen not refrigerated or frozen; insufficient specimen volume; inappropriate specimen source; inappropriate specimen collection device (ie, urine collected/submitted in a maintenance fluid or a preservative such as boric acid); specimen stability exceeded; name discrepancy between the name on the specimen container and the name in the computer or on the requisition