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Test ID: 


CPT code:



  • Acute Phase Proteins
  • Alpha1-Protease Inhibitor

Clinical Use:

Detection of hereditary decreases in the production of α1-antitrypsin (α1AT). Decreased or nearly absent levels of α1AT can be a factor in chronic obstructive lung disease and liver disease. An increased prevalence of non-MM phenotypes is found with cryptogenic cirrhosis and with CAH. Cirrhosis in a child should raise consideration of α1AT deficiency or Wilson’s disease. Diagnosis of inflammatory states, if elevated (eg, rheumatoid arthritis, bacterial infection, vasculitis, neoplasia).

Test Information:

Should be run when α1-globulin in serum protein electrophoresis is low or when two bands are seen in the α1-region. Heterozygous patients exhibit AAT levels which are commonly about 60% of normal. Homozygous recessive α1AT patients exhibit levels at about 10% of normal. Phenotyping is desirable on patients with low values and on all patients being worked up for AAT-deficient liver disease. Most pathologic is homozygous state ZZ. An M null genotype will have phenotype as MM but low serum level. AAT is one of the alpha-globulins, which together are called “acute phase reactants.” These rise rapidly, but nonspecifically, in response to inflammatory insults.

Specimen Type:

Serum (preferred) or plasma

Requested Volume: 

1 mL

Minimum Volume: 

0.5 mL (Note: This volume does not allow for repeat testing.)

Container Type: 

Red-top tube, gel-barrier tube, lavender-top (EDTA) tube, or green-top (heparin) tube.


Separate serum or plasma from cells.

Storage Instructions:

Maintain specimen at room temperature.

Stability Requirements:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Rejection Criteria:

Chylous serum

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